The Ñuble Region (Spanish: Región de Ñuble), officially the Region of Ñuble (Spanish: Región de Ñuble), is since 5 September 2018 one of Chile's sixteen regions. It spans an area of 13,178.5 sq km (5,088 sq mi), making it the smallest region in Chile in terms of area, and is administratively constituted by 21 communes. It has a population of 480,609 inhabitants.

The Libertador General Bernardo O'Higgins Region (Spanish: Región del Libertador General Bernardo O'Higgins, pronounced [liβeɾtaˈðoɾ xeneˈɾal βeɾˈnaɾðo oˈçiɣins]), often shortened to O'Higgins Region (Spanish: Región de O'Higgins), is one of Chile's 16 first order administrative divisions. It is subdivided into three provinces. It is named in honor of Bernardo O'Higgins Riquelme, one of Chile's founding fathers.

The Valparaíso Region (Spanish: Región de Valparaíso, pronounced [balpaɾaˈiso]) is one of Chile's 16 first order administrative divisions. With the country's second-highest population of 1,790,219 as of 2017, and fourth-smallest area of 16,396.1 km2 (6,331 sq mi), the region is Chile's second most densely populated after the

The Atacama Region (Spanish: Región de Atacama, pronounced [ataˈkama]) is one of Chile's 16 first order administrative divisions.